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Nuvalent Inc

Nuvalent, Inc., a clinical-stage biopharmaceutical company, engages in the development of therapies for patients with cancer. Its lead product candidates are Zidesamtinib (NVL-520), a novel ROS1-selective inhibitor to address the clinical challenges of emergent treatment resistance, central nervous system (CNS)-related adverse events, and brain metastases that may limit the use of ROS1 tyrosine kinase inhibitors (TKIs) for patients with ROS proto-oncogene 1 (ROS1)-positive non-small cell lung cancer (NSCLC) which is under the Phase 2 portion of the ARROS-1 Phase 1/2 clinical trial; Neladalkib (NVL-655), a brain-penetrant ALK-selective inhibitor, to address the clinical challenges of emergent treatment resistance, CNS-related adverse events, and brain metastases that might limit the use of first-, second-, and third-generation ALK inhibitors that is under the Phase 2 portion of the ALKOVE-1 clinical trial; and NVL-330, a brain-penetrant human epidermal growth factor receptor 2 (HER2)-selective inhibitor designed to treat tumors driven by HER2ex20, brain metastases, and avoiding treatment-limiting adverse events including due to off-target inhibition of wild-type EGFR that is in Phase 1a/1b clinical trial. Nuvalent, Inc. has a strategic partnership with Guardant Health, Inc. to develop companion diagnostics therapies. The company was incorporated in 2017 and is headquartered in Cambridge, Massachusetts.

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GSK Q2 earnings expected to plunge 97% ahead of CEO strategy event

GSK is expected to report a 97.3% year-over-year decline in earnings per share when it releases second-quarter results on Tuesday before the market opens. The consensus EPS estimate stands at $1.25, while revenue is forecast to rise 37.4% to $10.98 billion. The company’s Specialty Medicines unit, which includes respiratory, immunology and inflammation, oncology, and HIV, is projected to deliver double-digit sales growth across all therapy areas, though generic competition for certain legacy products may pose a headwind. On the same day, CEO Luke Miels will host an “Accelerate Growth” event where he is expected to outline his strategy, with analysts at UBS focusing on whether he can provide a credible path to achieving the sales target of more than £40 billion by 2031 and an update on pipeline reprioritization following the acquisition of Nuvalent.
Seeking Alpha·30dRead more ▾
Biotech & Genomic Medicineimpact 4

GSK's First Lung Cancer Drug Wins Early FDA Approval

British pharmaceutical giant GSK announced that its first lung cancer drug, Jiditro, has received marketing approval from the US Food and Drug Administration. The approval came ahead of the original review deadline, allowing GSK to enter the highly profitable lung cancer treatment market. Jiditro was acquired from the US biopharmaceutical company Newvalent, which GSK bought for 10.6 billion dollars about two months ago. It has been approved for patients with previously treated ROS1-positive non-small cell lung cancer. In early to mid-stage clinical trials, tumors shrank or disappeared in 44 percent of 117 patients, and among those who responded, 82 percent maintained their response at six months and 69 percent at twelve months. With this approval, GSK aims to accelerate the turnaround of its oncology business under new CEO Luke Miles and achieve its target of over 40 billion pounds in revenue by 2031.
Reuters·35dRead more ▾
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Brodsky & Smith investigates boards of five companies over merger fairness

Brodsky & Smith is investigating the boards of Personalis, Distribution Solutions Group, Cross Country Healthcare, Nuvalent, and Dana Incorporated for potential fiduciary duty breaches in connection with their proposed acquisitions. Personalis is being acquired by Tempus AI for $16.25 per share, representing a total enterprise value of $1.5 billion net of Tempus’ existing ownership. Distribution Solutions Group is being acquired by LKCM Headwater Investments for $35.00 per share in cash, with LKCM Headwater and its affiliates already owning approximately 79% of the company’s outstanding common stock. Cross Country Healthcare is being acquired by Knox Lane for $13.25 per share in an all-cash transaction valued at $437 million. Nuvalent is being acquired by GSK for $124.00 per share in cash in a deal valued at $10.6 billion. Dana is being acquired by Eaton in a transaction valued at approximately $5.1 billion, where Eaton shareholders will own at least 50.1% and Dana shareholders approximately 49.9% of the combined company at close, and Eaton will receive a cash distribution of approximately $1.1 billion. The investigations focus on whether the boards failed to conduct a fair process and whether the proposed transactions pay fair value to shareholders.
GlobeNewswire·36dRead more ▾
Biotech & Genomic Medicine

Biotech IPOs Deliver 55% Return, Crushing AI Listings

US biotech and pharmaceutical IPOs have delivered a weighted average return of 55% this year, far outpacing the broader US IPO market's 4.4% weighted average loss, according to Bloomberg data. At least six biotechs, led by CRISPR-based genetic medicines developer Scribe Therapeutics Inc., have filed for IPOs this month that could price later in July and the first half of August. The sector's outperformance is driven by a 13% gain in the Nasdaq Biotechnology Index, a stable regulatory backdrop, notable trial data breakthroughs, and big pharma acquisitions, including Abbvie Inc.'s purchase of Apogee Therapeutics Inc., GSK Plc's deal for Nuvalent Inc., and Vertex Pharmaceuticals Inc.'s purchase of Crinetics Pharmaceuticals Inc. Proceeds from biotech IPOs this year have topped $5 billion, three times last year's total, and include the biggest-ever biotech listing, Parabilis Medicines Inc.'s $770.6 million offering. Pattern hair loss drug company Veradermics Inc. is up over 500% since its February debut, making it the best performing US IPO from any sector this year.
Bloomberg·36dRead more ▾
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Halper Sadeh LLC Investigates Fairness of Deals for DAN, ESI, NUVL, BOLD Shareholders

Halper Sadeh LLC, an investor rights law firm, is investigating whether the proposed transactions involving Dana Incorporated, Element Solutions Inc, Nuvalent Inc, and Boundless Bio Inc are fair to their shareholders. The firm is examining Dana's sale to Eaton Corporation, where Dana shareholders would own approximately 49.9% of the combined company, and Element Solutions' sale to Solstice Advanced Materials for $10.00 in cash and 0.500 shares of Solstice common stock per Element share, with Element shareholders expected to own about 44% of the combined entity. It is also looking into Nuvalent's sale to GSK for $124.00 per share in cash and Boundless Bio's merger with Serapha Bio, where Boundless Bio shareholders would hold roughly 3.7% of the combined company. Halper Sadeh may seek increased consideration or additional disclosures on behalf of shareholders, who can contact the firm at no cost to discuss their legal rights.
GlobeNewswire·51dRead more ▾
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Halper Sadeh LLC Investigates Whether LCII, NUVL, DAN, TMHC Are Obtaining Fair Deals for Their Shareholders

Halper Sadeh LLC, an investor rights law firm, is investigating LCI Industries, Nuvalent, Dana Incorporated, and Taylor Morrison Home Corporation for potential violations of federal securities laws or breaches of fiduciary duties to shareholders in connection with their proposed sales. The firm is examining LCI Industries' sale to Patrick Industries for 1.2440 shares of Patrick common stock per LCI share, Nuvalent's sale to GSK for $124.00 per share in cash, Dana's sale to Eaton Corporation where Dana shareholders would own approximately 49.9% of the combined company, and Taylor Morrison's sale to Berkshire Hathaway for $72.50 per common share in cash. Halper Sadeh LLC may seek increased consideration, additional disclosures, or other relief on behalf of shareholders, and encourages them to contact the firm to discuss their rights at no cost.
GlobeNewswire·57dRead more ▾
Biotech & Genomic Medicine

GSK Launches Tender Offer to Acquire Nuvalent for $124 Per Share

GSK announced that its indirect wholly owned subsidiary, Harmony Row Acquisition Co., has formally launched a tender offer to acquire all outstanding Class A and Class B common shares of Nuvalent for $124.00 per share in cash. The offer is being made pursuant to the previously announced merger agreement signed on June 9, 2026, and represents the next step toward completing the planned acquisition. The tender offer is subject to applicable withholding taxes and the conditions outlined in the offer documents.
TheFly·57dRead more ▾
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Brodsky & Smith investigates Arcosa, Fathom, Nuvalent, and Dana boards over merger deals

Brodsky & Smith is investigating the boards of Arcosa, Fathom Holdings, Nuvalent, and Dana Incorporated over potential fiduciary duty breaches in their respective merger agreements. Arcosa is being acquired by CRH for $150.00 per share in cash, with a total enterprise value of approximately $8.5 billion. Fathom Holdings is being acquired by Bed Bath & Beyond in a deal implying an equity value of about $53.38 million, with an exchange ratio of 0.2236 Bed Bath & Beyond shares per Fathom share. Nuvalent is being acquired by GSK for $124.00 per share in cash in a deal valued at $10.6 billion. Dana is being acquired by Eaton Corporation in a transaction valued at approximately $5.1 billion, where Eaton shareholders will own at least 50.1% and Dana shareholders approximately 49.9% of the combined company, and Eaton will receive a cash distribution of about $1.1 billion.
GlobeNewswire·65dRead more ▾
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Biopharma industry confidence hits four-year high despite geopolitical headwinds

Biopharma executives' confidence in the industry has reached its highest point in four years, with 55% of surveyed professionals feeling optimistic or very optimistic about growth over the next 12 months, up from 46% in 2023, according to GlobalData's State of the Biopharmaceutical Industry 2026 mid-year update. The survey of 157 pharmaceutical professionals found that 69% of respondents highlighted US tariffs and government actions as the biggest policy concern, a figure that rose to 78% among European respondents. Deal activity has surged, with first-quarter 2026 M&A deal value rising 71% year over year and life sciences and pharma deals surpassing $65 billion, the strongest quarter since 2020. Notable transactions include Eli Lilly's acquisition of 10 companies this year, led by a $7.8 billion deal for Centessa, while the second quarter saw Sun Pharma's $11.75 billion takeover of Organon and GSK's $10.6 billion acquisition of Nuvalent. The IPO market has also resurged, with activity up 210%, and Parabilis Medicines set a new biotech IPO record with a $670 million Nasdaq listing just two months after Kailera Therapeutics raised $625 million.
Pharmaceutical Technology·68dRead more ▾
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Monteverde & Associates Investigates Four Mergers Involving PFLC, NUVL, CCRN, and BGMS

Monteverde & Associates PC, a class action law firm, is investigating four proposed mergers. The firm is looking into Pacific Financial Corporation's merger with Banner Corporation, where Pacific Financial shareholders are expected to receive 0.2633 share of Banner common stock for each share held, with a shareholder vote scheduled for August 12, 2026. It is also investigating Nuvalent, Inc.'s sale to GSK plc for $124.00 per share in cash, Cross Country Healthcare, Inc.'s sale to KL Criss Cross Intermediate, LLC for $13.25 per share in cash with a shareholder vote set for July 16, 2026, and Bio Green Med Solution, Inc.'s merger with Future NRG Sdn. Bhd.
GlobeNewswire·69dRead more ▾
Biotech & Genomic Medicineimpact 4

Biopharma M&A hits six-year high with $65 billion in first-quarter deals

PwC reports that US pharma and life sciences deal value surpassed $65 billion in the first quarter of 2026, the strongest quarter since pandemic-related highs in 2020. The surge is driven by the largest patent cliff in industry history, with more than $300 billion in branded pharma revenue exposed, forcing companies to pursue acquisitions in areas like GLP-1 receptor agonists, RNA therapeutics, and antibody-drug conjugates. Eli Lilly has been the most active buyer, purchasing 10 companies this year including a $7.8 billion deal for Centessa. The momentum continued into the second quarter with Sun Pharma's $11.75 billion takeover of Organon and GSK's $10.6 billion acquisition of Nuvalent. PwC expects M&A to remain strong through year-end as large-cap pharma fills loss-of-exclusivity gaps, while a resurgent IPO market saw Parabilis Medicines raise a record $670 million in the largest biotech IPO ever.
Pharmaceutical Technology·70dRead more ▾
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Halper Sadeh LLC Investigates Fairness of Deals for LPRO, NUVL, OGN, SUNE Shareholders

Halper Sadeh LLC, an investor rights law firm, is investigating whether the proposed sales of Open Lending Corporation, Nuvalent Inc., Organon & Co., and SUNation Energy Inc. are fair to shareholders. The firm is examining Open Lending's sale to ANV Group Holdings Ltd. for $3.15 per share, Nuvalent's sale to GSK plc for $124.00 per share in cash, Organon's sale to Sun Pharmaceutical Industries Limited for $14.00 per share, and SUNation Energy's merger with Suniva, in which SUNation shareholders would own approximately 1.8% of the combined company. Halper Sadeh LLC may seek increased consideration, additional disclosures, or other relief on behalf of shareholders, and encourages investors to contact the firm to discuss their rights at no cost.
GlobeNewswire·71dRead more ▾